KARAKTERISASI SENYAWA TURUNAN AMOKSISILIN HASIL REAKSI ANTARA AMOKSISILIN DENGAN 4t-BUTILBENZOIL KLORIDA

HADI BARRU HAKAM FAJAR SIDDIQ, DEWI RASHATI, DIAH RAHAYU WULANDARI

Abstract


The synthesis of amoxicillin derivate has been done by reacting amoxicillin with 4t-butylbenzoil chloride. The products were characterized by organoleptic test, melting point determination, TLC, and UV/Vis Spectrophotometry. This product has been characteristic such as powder, light yellow, and bite bitter. Melting point of product was 132 °C. Rf value of product was 0.86. pH value of product amoxicillin derivate was 7.7. The results of UV wavelength scanning showed that product derivate of amoxicillin compounds had peak at 286 nm.


Full Text:

PDF

References


Buntaran, L. (2007). Infeksi Nosokomial: Menggantung Harapan pada Antibiotik Anyar, Farmacia. Vol. VI, no. 11.

Dzen, S.M, Roekistiningsih, S., Sanarto, dan Sri, W. (2003). Bakteriologi medik. Bayumedia Publishing. Malang

Finch, R., Hunter. P.A. (2006). Antibiotic resistance--action to promote new technologies: report of an EU Intergovernmental Conference held in Birmingham, UK, 12-13 December 2005. J. Antimicrob. Chemother., 58 Suppl 1.

Kumar. (2006). Organic Chemistry Sprctroscopy of Organic Compounds. https://www.coursehero.com/file/30238438/publication-11-8282-250pdf/. Diakses tanggal 23 Juli 2018

Kusumowati, Ika T. D., et al. (2011). Sintesis n-3-chlorobenzoylamoxicillin dan uji aktivitas Antibakterinya terhadap pseudomonas aeruginosa atcc 27853. Farmasains Jurnal Farmasi dan IlmuKesehatan. Vol. 1 No. 2.

Nah, Y.K., Rumawas, M., Wijaya, W.H. (2004). Survei Peresapan Antimikroba Oral untuk Anak Balita pada Apotek-Apotek di Wilayah Jakarta Barat. Meditek. Vol. 12. No. 32.

Nasiru, M. (2011). Effect of Cooking Time and Potash Concentration on Organoleptic Properties of Red and White Meat dalam Ayustaningwarno, F. 2014. Teknologi Pangan, Teori Praktis dan Aplikasi. Graha ilmu. Yogyakarta.

Putin, V. (2006). Masalah Pendidikan dan Penyakit Infeksi. Info Aktual. www.litbang.depkes.go.id/aktual/kliping/vladimir. Dikases tanggal 12 Desember 2017.

Ramos, F., et.al. (2012). Amoxicillin. http://docplayer.net/49371362-First-draft-prepared-by-fernando-ramos-coimbra-portugal-joe-boison-saskatoon-canada-and-lynn-g-friedlander-rockville-md-usa.html. Diakses tanggal 23 Juli 2018.

Shituu, A.O., Okon, K., Adesida, S., Oyedara, O., Witte, W., Strommrnenger, B., Layer, F. dan Nubel, U. (2011). Antibiotic Resistance and Molecular Epidemiology of Staphylococcus aureus in Nigeria. BMC Microbiology.Vol. 11. No. 92.

Siddiq, H. B. H. F., Eryani, M. C., Suryaningsih, F. (2018). Sintesis Analgetika-Antiinflamasi N-(4t-Butilbenzoil)-P-Aminofenol Menggunakan Katalis Heterogen MgF2. Jurnal Ilmu Dasar. Vol. 19. No. 1

Siswandono, Soekardjo, B (Editor). (1998). Prinsip-Prinsip Rancangan Obat. Airlangga University Press. Surabaya.

Soekardjo, B. (1989). Sintesis dan Hubungan Struktur dengan Aktivitas In vitro dari Suatu Seri Turunan Bensoil N-Ampisilin Baru. Disesrtasi. Universitas Airlangga. Surabaya.

Soekardjo, B., Siswandono. (2000). Sintesis Senyawa Baru Turunan N-Benzoilamoksisilin untuk Meningkatkan Aktivitas terhadap Bakteri Gram-Positif dan Gram-Negatif. Laporan Riset Unggulan terpadu VI Bidang Ilmu Kimia dan Proses.

Spellberg, B., Powers, J.H., Brass, P.E., Miller, L.G., Junior, J. E. E. (2004). Trends in Antimicrobial Drug Development: Implications for The Future. Clin. Infect. Dis. 38 (9).

Susilowati, S.S. dan Handayani, S.N. (2006). Sintesis dan Uji Aktivitas Analgetika Antiinflamasi Senyawa N-(4tbutilbenzoil)-p-Aminofenol. Molekul. Vol. 1. No. 1.

Yoneyama, H., Katsumata, R. (2006). Antibiotic resistance in bacteria and its future for novel antibiotic development. Biotechnol. Biochem. 70 (5).


Refbacks

  • There are currently no refbacks.